Isothiocyanates. XLIII. Isothiocyanates from Putranjiva Roxburghii Wall. Including (S)-2-Methylbutyl Isothiocyanate, A New Mustard Oil of Natural Derivation.

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A review of pharmacological properties, pharmacognosy and therapeutic actions of Putranjiva roxburghii Wall. (Putranjiva)

Putranjiva roxburghii Wall. is a well-known plant which has been ascribed an important role in Ayurvedic texts as an antipyretic, anti-inflammatory & anti-rheumatic herb useful in gynaecological and fertility ailments. The pharmacognosy of its leaves, fruits, root and stem bark indicates the presence of many glycosides, saponins, triterpenes and flavonoids. Its leaf extract has been found suita...

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Isothiocyanates: a review

Isothiocyanates (ITCs) are naturally occurring molecules belonging to highly reactive organosulphur synthons, with the general structure R–N=C=S. The precursor molecule glucosinolate anions are hydrolyzed enzymatically (under the effect of myrosinase enzymes) or unenzymatically to produce nitriles or isothiocyanates depending upon conditions such as pH and temperature. Brassicaceae  Family is k...

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Hydroxy Isothiocyanates

antifungal and antibacterial activities at concentrations of 7.8 to 15,6uglml, respectively, and that a possible target of the ITC compounds might be the cellular sulfhydryl group, In recent years, a number of multidrug transporters have been found in various organisms including bacteria and human cells.3) A promising way to conquer such multidrug resistance is to inactivate the eMux protein in...

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Chemoprevention by isothiocyanates.

Naturally occurring and synthetic isothiocyanates are among the most effective chemopreventive agents known. A wide variety of isothiocyanates prevents cancer in the rat lung, mammary gland, esophagus, liver, small intestine, colon, and bladder. Mechanistic studies have shown that this chemopreventive activity is due to favorable modification of phase I and phase II carcinogen metabolism, resul...

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Glucosinolates, isothiocyanates and indoles

Although isothiocyanate and indole compounds derived from cruciferous vegetables appear to be structurally unrelated, they are both derived from glucosinolates. These sulfur-containing glycosides are found in the order Capparales, which includes the large family Brassicaceae. The glucosinolate molecule comprises a common glucone moiety and a variable aglucone side-chain, derived from one of sev...

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ژورنال

عنوان ژورنال: Acta Chemica Scandinavica

سال: 1962

ISSN: 0904-213X

DOI: 10.3891/acta.chem.scand.16-0936